We adopt procedures to minimize issues of sample contamination during bioanalysis.
Majority of our methods still use manual extraction techniques to minimize potential for sample contamination compared to that observed using automated liquid handling devices.
We keep our calibration ranges narrow and appropriate for the administered dose.
For bio-studies requiring PK analysis following both low and high dose drug administration, we prefer to offer our clients validated methods with different calibration ranges rather than a single validated assay with a very broad range.